Born on 6 October 1980 , Hassan is the middle son of Mohammed Abdul Latif Jameel, who has been the chairman and president of the diversified international business Abdul Latif Jameel since 1993. He is the grandson of Abdul Latif Jameel (1909–1993), who founded the eponymous company in 1945 and acquired distribution rights to Toyota vehicles in Saudi Arabia in 1955.
Jameel is Vice Chairman of Community Jameel, an organization founded in 2003. The organization has a wide range of social and economic initiatives, including refugee education, job creation, poverty alleviation, food and water security, healthcare improvement, and education and training that supports students beyond the classroom. It also invests in businesses aimed at helping communities transform themselves. Community Jameel also supports artists showcasing their work, and promotes arts and culture. It partners with MIT on global challenges such as health treatment, water and food safety, education for refugees, and poverty elimination, and launched the Abdul Latif Jameel Poverty Action Lab in 2003. Bab Rizq Jameel Saudi Arabia, a division of Community Jameel, creates job opportunities for, and offers guidance to, young Saudi men and women, and also offers interest-free microfinance loans for entrepreneurship and job creation. Jameel is particularly involved in Community Jameel's road safety initiative, which promotes safe driving through education and awareness campaigns.
In 2004, Jameel trained at the Toyota Motor Corporation in Japan, in their domestic kaizen department.
Jameel spent his early school career in Japan. He received a BA in International Economics from Sophia University in Tokyo in 2010. He subsequently obtained an MBA from the London Business School.
In 2012 Jameel married Tunisian art critic, art curator, and Sotheby's international contemporary art specialist Lina Lazaar. An activist promoter of Middle Eastern art, she founded Jeddah Art Week and co-founded Ibraaz. The marriage ended in divorce in 2017.