Born in Coeur d'Alene, Idaho, on November 22, 1990, Osweiler was raised by his parents, Kathy and John Osweiler, in Kalispell, Montana. Osweiler attended Flathead High School. His older brother, Tanner, played college football in the National Association of Intercollegiate Athletics (NAIA) at Montana Tech in Butte. Their father received scholarship offers to play football at Montana and Montana State but ultimately chose to enter the military out of high school.
Brock Alan Osweiler (born November 22, 1990) is an American former professional football quarterback who played in the National Football League (NFL) for seven seasons. He played college football for the Arizona State Sun Devils and was selected by the Denver Broncos in the second round of the 2012 NFL draft. Osweiler first served as the Broncos' starter during their Super Bowl-winning season in 2015 when he relieved an injured Peyton Manning and helped Denver get the top seed in the AFC heading into the postseason, although Manning resumed his starting duties for the playoffs and eventual Super Bowl 50 victory.
As a true freshman in 2009, Osweiler played in six games with one start. He became the first true freshman to start a game for the Sun Devils since Jake Plummer in 1993. Osweiler finished the season completing 24 of 55 passes for 249 yards, two touchdowns, and two interceptions.
Osweiler played both football and basketball; football was the dominant sport in Montana, so he traveled to neighboring states to play for Amateur Athletic Union (AAU) basketball teams in Portland, Oregon, and Seattle, Yakima, and Spokane, Washington. In 2006, after his freshman year of high school, Osweiler committed to Gonzaga University in Spokane to play basketball, but later decided to focus on playing college football. As a senior, he was the 2008–09 Gatorade Player of the Year in football for Montana after he completed 189 of 303 passes for 2,703 yards and 29 touchdowns; Osweiler also rushed for 700 yards on 162 carries with 13 touchdowns.
As a sophomore in 2010, Osweiler again played in six games with one start. For the season, he completed 62 of 109 passes for 797 yards and five touchdowns to go along with 38 carries for 124 yards and a touchdown.
As a junior in 2011, Osweiler took over as the Sun Devils starting quarterback after the retirement of Steven Threet. He finished the season with 4,036 passing yards, 26 touchdowns, and 13 interceptions to go along with 90 rushing yards and three touchdowns.
Osweiler married Erin Costales in February 2015. They have two daughters.
On December 15, it was announced that Osweiler would start his fifth consecutive game against the Pittsburgh Steelers, despite the fact that Manning had returned to practice. Osweiler finished the 34–27 road loss with 296 passing yards, three touchdowns, and an interception to go along with five carries for 19 yards and a touchdown. During Week 16, Osweiler started his sixth consecutive game against the Cincinnati Bengals, completing 27-of-39 passes for 299 yards and a touchdown in the 20–17 overtime comeback victory. In the regular season finale against the Chargers, Osweiler was replaced by Manning in the third quarter after throwing for 232 yards, a touchdown, and two interceptions with one fumble. Manning led the Broncos to a 27–20 victory and helped them secure the top seed in the AFC. On January 7, 2016, the team announced that Osweiler suffered a low-grade strain to the MCL of his right knee in the game against the Chargers.
On March 9, 2016, Osweiler signed a four-year, $72 million contract ($37 million guaranteed) with the Houston Texans.
In his Texans debut on September 11, 2016, Osweiler threw for 231 yards, two touchdowns, and an interception during the season-opening 23–14 victory over the Bears. Despite his strong start, Osweiler began to struggle as the season progressed. During a Week 7 road game against his former team, the Denver Broncos, he had a total of three fumbles with one lost as the in the 27–9 road loss. During a Week 12 21–13 loss to the Chargers, Osweiler threw for 246 yards, no touchdowns, and three interceptions, but he did contribute a one-yard rushing touchdown.
On March 9, 2017, Osweiler was traded to the Cleveland Browns along with the Texans' 2017 sixth-round pick and 2018 second-round pick in exchange for the Browns' 2017 fourth-round compensatory pick. This trade was termed by ESPN's Adam Schefter as possibly the most creative trade in NFL history. The move allowed Cleveland to absorb some of Osweiler's cap from Houston in exchange for draft picks, one of the first trades of its kind.
On September 2, 2017, Osweiler signed a one-year contract with the Broncos after backup quarterback Paxton Lynch sustained a shoulder injury. His contract was worth the league-minimum $775,000, leaving the Browns to pay the remaining $15.25 million of Osweiler's $16 million guaranteed.
On September 2, 2017, Osweiler was released after rookie DeShone Kizer was named the starter.
On March 23, 2018, Osweiler signed a one-year deal worth $880,000 with the Miami Dolphins, reuniting him with his former Broncos offensive coordinator Adam Gase.
On October 16, 2019, Osweiler announced his retirement from the NFL.
In 2022, Osweiler joined ESPN as a college football analyst. Two years later, it was announced that he would serve as an ambassador for SHARx, a patient advocacy company for uninsured and underinsured Americans. In a statement announcing his ambassadorship, Osweiler said: "This is a passion of mine because it hits so close to home. Those closest to me have experienced the loss of loved ones because the high price of the drugs they needed made access impossible."
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