Boyce was born in Los Angeles, California, on May 28, 1999. His father is of Afro-Caribbean and African-American descent. His mother is Jewish. His paternal grandmother, Jo Ann (Allen) Boyce, was one of the Clinton Twelve, the first African-Americans to attend an integrated high school in the Southern United States, in 1956, as ordered by Brown v. Board of Education.
In May 2008, Boyce made his television debut in the music video "That Green Gentleman (Things Have Changed)", appearing as a younger version of Panic! at the Disco guitarist Ryan Ross. In July 2008, he appeared in General Hospital: Night Shift as a recurring character named Michael. In August 2008, he made his feature film debut with a starring role in the horror film Mirrors, as well as appearing in the mystery-thriller film Eagle Eye that fall.
In June 2010, Boyce starred as Keith, the spoiled son of Adam Sandler's character, in the comedy film Grown Ups and appeared later that same year showing off his dance skills on the web series The Legion of Extraordinary Dancers.
In April 2011, Boyce made a guest appearance on Disney Channel's comedy series Good Luck Charlie, and later that month he was one of the featured dancers in a royal wedding tribute on ABC's Dancing with the Stars. In June 2011, he had a small role as one of Judy's classmates in the family comedy film Judy Moody and the Not Bummer Summer. In August 2011, he was one of the featured dancers on Disney Channel's comedy series Shake It Up.
In September 2011, Boyce was cast in the starring role of Luke Ross on Disney Channel's comedy series Jessie. During pre-production of the series, the role of Luke was originally intended to be a boy named Hiro adopted from Korea, but casting directors were impressed with Boyce during the audition process and ultimately decided to recreate the role specifically for him.
He also supported United Way of America's initiative to end homelessness. He helped raise money for the HomeWalk in 2015, and continued to do so up until the end of his life. In May 2019, he participated in the opening ceremony of the 12th annual HomeWalk in downtown Los Angeles, one of the largest public events to end homelessness in the United States.
In 2015, Boyce was one of the main cast members in Disney Channel's Descendants, playing Carlos, the son of Cruella de Vil. He later reprised the character for the animated shorts Descendants: Wicked World and in the sequels Descendants 2 and Descendants 3, the latter of which was released posthumously.
In the span of 40 days in 2017, Boyce helped raise over $27,000 for the Thirst Project, which helps bring clean water to underdeveloped countries. In September 2019, Thirst Project officially changed the name of the Pioneering Spirit Award to the Cameron Boyce Pioneering Spirit Award, to honor his work with the organization.
In March 2018, Boyce was cast in the ABC comedy television pilot Steps, in the role of Becker, and was also cast in the indie film Runt, in the role of Cal.
The Cameron Boyce Foundation is a nonprofit organization founded in Los Angeles that provides young people artistic and creative outlets as alternatives to violence and negativity and uses resources and philanthropy for positive change in the world. The foundation was established in 2019 through Network for Good to honor Boyce's legacy in the wake of his death, receiving notable support from actors Debby Ryan, Karan Brar and Sophie Reynolds, among others.
In January 2019, Boyce had joined the cast of HBO's Mrs. Fletcher. In April 2019, Boyce performed in the music video for "Almost (Sweet Music)" by Hozier. He choreographed the dance with dancer Christine Flores, who appeared in the video alongside him. Just prior to his death, Boyce was to begin production with Adam Sandler on a new project. In September 2019, it was announced that his clothing line called Archives, co-founded by him and stylist and designer Veronica Graye, would be released in November 2019.
Boyce lived in the Los Angeles area with his parents and his younger sister, until he moved in with former co-stars Karan Brar and Sophie Reynolds in May 2019. He was trained in breakdancing, hip-hop, modern dance, jazz, tap dance, and ballet. His favorite style was breakdancing, and, along with four of his friends, he was a member of the breakdancing crew "X Mob".
On July 6, 2019, Boyce was found unresponsive at his home address. Authorities were called, and Boyce was pronounced dead at the scene.
According to a statement made by Boyce's family, Boyce died in his sleep at his home in Los Angeles "due to a seizure which was a result of an ongoing medical condition for which he was being treated". An autopsy was performed, but release of a cause of death was deferred, until further investigation was done. On July 9, 2019, Boyce's family confirmed that his death was caused by an epileptic seizure and that Boyce had previously been diagnosed with epilepsy. The autopsy results were released by the Los Angeles County Department of Medical Examiner-Coroner on July 30, 2019, confirming Boyce's cause of death was due to sudden unexpected death in epilepsy.
On July 25, 2019, the foundation disclosed the first project to be carried out was Wielding Peace, which officially launched on August 16, 2019. It has involved Brar, Reynolds, and the actor's cousin photographer Taryn Dudley from the beginning.
In September 2019, the foundation revealed that they donated $8,000 to Thirst Project to build a well in Uganda.