Natasha Lyonne is a multifaceted American entertainer, working as an actress, director, comedian, producer, writer, and tech executive. Beginning her career as a child actress with roles in *Heartburn* and *Pee-wee's Playhouse*, she transitioned to teen roles in independent films such as *Everyone Says I Love You*, *Slums of Beverly Hills*, *But I'm a Cheerleader*, and *Party Monster*, as well as the *American Pie* film series. Her career has led to her being nominated for multiple Primetime Emmy Awards and Golden Globe Awards. She was also recognized as one of Time Magazine's 100 most influential people in the world in 2023.
In 1957, Giulietta Masina in Nights of Cabiria was one of Natasha Lyonne's favorite film performances.
In 1974, Gena Rowlands in A Woman Under the Influence was one of Natasha Lyonne's favorite film performances.
In 1979, Roy Scheider in All That Jazz was one of Natasha Lyonne's favorite film performances.
In 1980, the film Out of the Blue came out. Both Natasha Lyonne and Chloë Sevigny have cited the film as an influence and crowdfunded it's restoration in 2019.
In 1993, David Thewlis in Naked was one of Natasha Lyonne's favorite film performances.
In 1997, Natasha Lyonne used her paycheck from Everyone Says I Love You to buy an apartment near Gramercy Park.
In 2005, Natasha Lyonne was admitted—under a pseudonym—to Beth Israel Medical Center in Manhattan, suffering from hepatitis C, infective endocarditis, and a collapsed lung; she was also undergoing methadone treatment for heroin addiction.
In 2005, Natasha Lyonne was evicted by her landlord, actor Michael Rapaport, following complaints by other tenants about her behavior.
In January 2006, a warrant was issued for Natasha Lyonne's arrest after she missed a court hearing relating to her prior legal problems.
Natasha Lyonne began an extended period of sobriety beginning in December 2006.
In 2012, Natasha Lyonne underwent open-heart surgery to correct heart valve damage caused by her previous heart infection.
In 2014, Natasha Lyonne began dating comedian and actor Fred Armisen.
In 2015, Natasha Lyonne was awarded the Human Rights Campaign's Ally for Equality Award for her position in the LGBT community as a 'straight ally'.
In 2019, Natasha Lyonne and Chloë Sevigny helped organize a crowdfund to restore the 1980 film Out of the Blue from its original elements.
In 2019, Natasha Lyonne co-founded the production company Animal Pictures with Maya Rudolph.
In 2019, Natasha Lyonne designed a crossword for The New York Times.
In 2020, Animal Pictures' first greenlit project was the sketch comedy special Sarah Cooper: Everything's Fine, which Natasha Lyonne directed.
In April 2022, Natasha Lyonne confirmed that her relationship with comedian and actor Fred Armisen had ended.
In 2022, Natasha Lyonne co-founded the artificial intelligence film studio Asteria with her boyfriend Bryn Mooser.
In October 2023, Maya Rudolph parted ways with Animal Pictures, leaving Natasha Lyonne to operate the company by herself under the Animal banner.
As of 2023, Natasha Lyonne lives in New York City's East Village and owns a residence in Los Angeles.
During the 2023 WGA strike, Natasha Lyonne auctioned off the opportunity for fans to solve a New York Times crossword with her to raise money for the Union Solidarity Coalition.
Natasha Lyonne quit smoking in 2023.
In May 2024, Natasha Lyonne's company Animal Pictures signed a deal with production company Sister to collaborate on upcoming Animal projects.
In September 2024, it was announced that Animal Pictures, along with Objective Fictions, would produce a new "retro series for Sky titled Force & Majeure" starring Natasha Lyonne and Matt Berry.
Natasha Lyonne resumed smoking in 2024.
In June 2025, Natasha Lyonne publicly announced her relationship with Bryn Mooser.
In June 2025, Natasha Lyonne publicly announced the existence of Asteria and her position as its co-founder to the world at large.
On 26 January 2026, Natasha Lyonne posted on Twitter, "#comingout #queer."
After an extended period of sobriety beginning in December 2006, Natasha Lyonne relapsed in 2026.
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