The Pittsburgh–Syracuse football rivalry is a college football series that started in 1916 and has been played annually since 1955. Both teams were largely independent before joining the Big East in 1991 and later the ACC in 2013. Syracuse is Pitt's most-played opponent, while Pitt is Syracuse's third-most-played opponent. As cross-divisional opponents in the ACC, the rivalry continues with consistent matchups. Following the ACC's division elimination in 2023, Pittsburgh and Syracuse were named primary opponents, guaranteeing yearly games. Pittsburgh leads the overall series with a record of 45-32-3 in 81 games played.
From 1916 to 1956, Pittsburgh led the series with a record of 8–2–2 against Syracuse.
In 1916, the Pittsburgh–Syracuse football rivalry began. They have played a total of 81 times, with Pittsburgh leading the series 45–32–3.
In 1923, the Pittsburgh and Syracuse teams played the first-ever collegiate football game at the original Yankee Stadium.
In 1955, the Pittsburgh–Syracuse game became an annual event, continuing each year since.
From 1973 to 1983, Pittsburgh achieved an 11-year winning streak against Syracuse.
In 1979, Syracuse was a charter member of the Big East Conference, which was initially prioritized for basketball and did not sponsor football.
In 1982, Pittsburgh joined Syracuse as a member of the Big East Conference.
From 1984 to 2001, Syracuse had a successful period against Pittsburgh, going 16–1–1 and taking the series lead.
In 1991, both Pittsburgh and Syracuse moved their football teams, both playing as Independents, into the Big East Football Conference, along with other football-playing members and additional Eastern independent teams.
In 1991, the Pittsburgh Panthers and Syracuse Orange shared the same football conference after the Big East Football Conference was formed from Eastern football independents.
Since 1991, Pittsburgh and Syracuse have played twenty-two times while in the Big East.
From 1984-2001, Syracuse went 16-1-1 to take the series lead (29-25-3).
In 2005, trouble began to rumble through the Big East Conference, between the "football" and "non-football" schools of the conference, which led to instability.
On September 18, 2011, Pittsburgh and Syracuse had their formal applications to join the ACC accepted.
On July 1, 2013, Pittsburgh and Syracuse officially joined the ACC.
In 2013, the Pittsburgh Panthers and Syracuse Orange shared membership in the Atlantic Coast Conference (ACC).
In 2016, the game between Pittsburgh and Syracuse aired on Pittsburgh ABC affiliate WTAE-TV's main signal, while the Michigan and Ohio State game aired on ESPN2 and on the This TV digital subchannel.
On November 11, 2023, the Pittsburgh and Syracuse teams marked the 100th anniversary of their first game at Yankee Stadium by replaying at the new Yankee Stadium.
Beginning in 2023, the ACC eliminated the Atlantic and Coastal divisions, going to one division. The Pittsburgh Panthers and Syracuse Orange were designated primary opponents, ensuring they will meet annually.
In 2023, after additions of California, SMU, and Stanford, the ACC announced a new scheduling format, which eliminated divisions and protects 16 annual matchups, retaining Pittsburgh–Syracuse as a protected rivalry.
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