Addison's disease, or primary adrenal insufficiency, is a rare endocrine disorder caused by the adrenal glands' inadequate production of cortisol and aldosterone. Symptoms develop gradually and include abdominal pain, weakness, weight loss, and sometimes skin darkening. A life-threatening adrenal crisis, marked by low blood pressure, vomiting, and loss of consciousness, can be triggered by stress, injury, or infection. Rapid onset of symptoms indicates acute adrenal failure, requiring immediate medical attention. Mood changes can also occur.
In 1917, John F. Kennedy was born. He later suffered from complications of Addison's disease throughout his life.
In 1963, US President John F. Kennedy, who suffered from Addison's disease, passed away. He was one of the most famous known cases of Addison's disease.
In 1983, hypoadrenocorticism was first documented in cats.
In 1992, the autoimmune reaction against the enzyme 21-hydroxylase was first described as a cause of autoimmune destruction of the adrenal cortex.
 
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