"Addison's disease, or primary adrenal insufficiency, is a rare endocrine disorder. It involves insufficient production of cortisol and aldosterone by the adrenal glands. Symptoms develop gradually, including abdominal issues, weakness, weight loss, and skin darkening. In acute cases, an adrenal crisis may arise, marked by low blood pressure, vomiting, pain, and potential consciousness loss. This crisis often stems from stressors like injuries or infections and necessitates immediate medical attention."
1917: Birth of John F. Kennedy
John F. Kennedy, who suffered from complications of Addison's disease throughout his life, was born in 1917.
1963: Death of John F. Kennedy
John F. Kennedy, who suffered from complications of Addison's disease, including fatigue and hyperpigmentation of the face, throughout his life, passed away in 1963.
1983: First Documented Case of Hypoadrenocorticism in Cats
Hypoadrenocorticism in cats is rare, with the first documented case reported in 1983.
1992: Autoimmune Destruction of the Adrenal Cortex
In 1992, it was discovered that autoimmune destruction of the adrenal cortex, a common cause of Addison's disease, is caused by an immune reaction against the enzyme 21-hydroxylase.