Graves' disease is an autoimmune disorder and the primary cause of hyperthyroidism, often leading to an enlarged thyroid (goiter). Hyperthyroidism symptoms include irritability, muscle weakness, sleep disturbances, rapid heartbeat, heat intolerance, diarrhea, and unintentional weight loss. A significant portion of individuals with Graves' disease experience Graves' ophthalmopathy, characterized by eye bulging. Pretibial myxedema, or thickening of the skin on the shins, can also occur. Eye problems are observed in approximately 25-30% of cases, highlighting the systemic nature of this condition.
In 2013, a review article determined that surgery, particularly total thyroidectomy, is the most successful approach in managing Graves' disease.
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