Weatherford, Oklahoma, located in Custer County, experienced an 11.5% population increase between 2010 and 2020, reaching 12,076 residents. The historic Route 66 runs through the city's Main Street. Weatherford is home to the Stafford Air & Space Museum, which commemorates astronaut Thomas P. Stafford, adding to the city's attractions.
By 1900, Weatherford's population reached 1,017 residents.
In 1901, Southwestern Oklahoma State College was founded and was originally known as Southwestern State Teachers College.
In 1926, State Highway 3 was redesignated as U.S. Route 66, which passed through Weatherford along Main Street.
The Oklahoma Heartland of America Museum contains a 1931 Model A Ford sports coupe as part of its exhibits.
In 1960, Interstate 40 (I-40) was completed east and west of Weatherford, generally paralleling the old U.S. Route 66 alignment.
In July 1970, the I-40 bypass skirting Weatherford to the south was completed.
In 2007, the Oklahoma Heartland of America Museum, a 12,000 square foot building containing many artifacts from the late 1800s through the 1950s, opened.
The 2010 census recorded Weatherford's population at 10,833.
According to the 2015 census, Weatherford had a population of 12,126 people residing in 3,991 households, with a population density of 1,699.3 inhabitants per square mile.
By 2015, Southwestern Oklahoma State University (SWOSU) had grown to have more than 4,200 undergraduate and postgraduate students.
In 2017, Kodak's manufacturing plant in Weatherford underwent a $15 million expansion related to flexographic packaging plates.
In 2020, the census reported Weatherford's population as 12,076, reflecting an approximately 11.5% increase from the 2010 census figure.
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