María Camila Osorio Serrano is a Colombian professional tennis player. She achieved a career-high singles ranking of world No. 33 by the WTA on April 4, 2022, and a doubles ranking of No. 162 on September 8, 2025. She is currently the No. 2 singles player from Colombia.
In 2018, Osorio won a bronze medal in girls' singles and a silver medal in mixed doubles at the Summer Youth Olympics, partnering with Nicolás Mejía.
In September 2019, Osorio won the girls' singles title at the 2019 US Open, defeating Alexandra Yepifanova. She also advanced to world No. 1 on the ITF Junior Circuit in September 2019.
In April 2021, ranked world No. 180, Osorio won her first singles title at the Copa Colsanitas in Colombia, defeating Tamara Zidanšek in the final. She then made it to the Semifinals at the Charleston Open the following week.
In October 2021, Osorio completed her first professional season by reaching the final of the Tenerife Open, where she lost to Ann Li while sustaining an abdominal injury. On October 25, 2021, her success at the tournament led to a new career high of No. 53.
In 2021, Osorio reached her third Tour-level singles final at the Monterrey Open, losing to Leylah Fernandez after having multiple match points.
On April 2022, María Camila Osorio Serrano achieved a career-high singles ranking of world No. 33 by the WTA.
On April 4, 2022, Osorio reached a career-high ranking of No. 33.
In March 2023, at the Monterrey Open, Osorio retired in the first round against Mayar Sherif. On March 6, 2023, as a result of not defending her points, her ranking fell 30 positions to outside the top 100.
In May 2023, Osorio reached the third round of the Madrid Open, defeating Clara Burel and Marta Kostyuk. She also reached the third round of the Italian Open, defeating Varvara Gracheva and Petra Martić. She reached the fourth round with a win over Caroline Garcia, becoming the first Colombian woman to reach the round of 16 at a WTA 1000 tournament. As a result, on May 22, 2023, she returned to the top 85.
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