East Palestine is a village in northeastern Columbiana County, Ohio, United States. The 2020 census recorded a population of 4,761. Situated on Ohio's border with Pennsylvania, it lies approximately 20 miles south of Youngstown and 40 miles northwest of Pittsburgh.
In 1920, East Palestine reached a population of 5,000, and began operating as a statutory city.
In 1920, the public library in the village first opened.
In 1997, a new middle school and a renovated elementary campus were built surrounding the existing high school in the East Palestine City School District.
As of the census of 2000, East Palestine had a population of 4,917 people, 1,975 households, and 1,384 families.
In 2004, East Palestine was recognized as a qualified Tree City USA by the National Arbor Day Foundation.
As of the census of 2010, East Palestine had a population of 4,721 people, 1,898 households, and 1,282 families.
In 2011, East Palestine reverted to village status due to a declining population.
In 2020, the population of East Palestine was recorded at 4,761 according to the census.
Beginning in October 2022, the East Palestine Fire Department started to implement a new emergency response system utilizing the "MyID" digital health identity platform.
On January 29, 2023, a community information session was held regarding the new "MyID" digital health identity platform, with 60 participants signed up for the program.
On February 3, 2023, East Palestine was near the site of a major train derailment. The accident resulted in a spill of vinyl chloride, leading to significant evacuations in the surrounding area.
As of 2023, East Palestine operates under a chartered council–manager government; the mayor was Trent R. Conaway and the village manager was Chad M. Edwards.