In November 2013, activist investor Carl Icahn disclosed a 12.5% stake in Hologic, leading the company to adopt a poison pill to prevent a hostile takeover.
On March 3, 2016, Carl Icahn's nominees to Hologic's board of directors resigned.
On May 16, 2016, Carl Icahn exited his position in Hologic, considering his investment and intervention a success.
In 2017, Hologic acquired Cynosure, an aesthetic medicine company based in Westford, Massachusetts, for $1.65 billion.
On November 20, 2019, Hologic announced the divestment of Cynosure to Clayton, Dubilier & Rice for $205 million.
On December 30, 2019, Hologic completed the divestment of Cynosure to Clayton, Dubilier & Rice. Cynosure had approximately 825 employees at the time.
In May 2020, Hologic received a second emergency use authorization from the FDA for 2019-nCov to increase potential throughput of testing.
In March 2020, Hologic received emergency use authorization from the FDA for a test for SARS-CoV-2 to help mitigate the COVID-19 pandemic.
In May 2020, Hologic received a second emergency use authorization from the FDA for 2019-nCov to increase potential throughput of testing.
In June 2020, Hologic collaborated with Grifols to increase Spain's testing capacity for COVID-19.
In November 2020, Hologic won a $119 million contract from the U.S. Department of Health and Human Services and the Department of Defense to expand production facilities in Wisconsin, Maine, and California.
In January 2021, Hologic announced it would acquire Biotheranostics and its breast and metastatic cancer test portfolio for $230 million and SOMATEX for $64 million.
In April 2021, Hologic announced it will acquire Mobidiag, a molecular diagnostics firm with multiplex technology, for $795 million.
The acquisition of Mobidiag, which was announced in April 2021, completed in June 2021.
By January 2022, Hologic aimed to provide 13 million COVID tests per month as part of the $119 million contract won in November 2020.
In March 2022, Hologic became the title sponsor of the WTA Tour in women's professional tennis and was named the "official health partner" of the Women's Tennis Association.
In April 2024, Hologic agreed to acquire British medical device manufacturer Endomag for $310 million.
In 2025, Hologic acquired Gynesonics for $350 million. Gynesonics developed the Sonata System, an ultrasound imaging device for uterine fibroids.
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