Ibogaine, a psychoactive indole alkaloid from plants like Tabernanthe iboga, induces hallucinogenic and oneirogenic effects. Originating in Central African traditional practices, it's been researched, controversially, for treating substance use disorders. Its complex pharmacology involves interactions with multiple neurotransmitter systems, influencing opioid, serotonin, sigma, and NMDA receptors. Noribogaine, its primary metabolite, functions mainly as a serotonin reuptake inhibitor and κ-opioid receptor agonist.
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