Christina Applegate is an American actress best known for her role as Kelly Bundy in the sitcom Married... with Children (1987–1997). Beginning her career in early childhood, she transitioned into a successful film and television actress as an adult. Her work has earned her a Primetime Emmy Award, four Golden Globe Award nominations, and a Tony Award nomination.
In 2003, Christina Applegate was the spokesperson for the Lee National Denim Day, which raises millions of dollars for breast cancer education and research.
In 2008, Christina Applegate was diagnosed with an early stage of breast cancer, which was detected through an MRI. The cancer was reported as not life-threatening, and she underwent treatment and a double mastectomy, leading to a full recovery. She was found to have a BRCA1 mutation.
In 2009, Christina Applegate announced plans to return as the ambassador for Lee National Denim Day and also founded Right Action for Women, a charitable foundation dedicated to breast-cancer screening for women.
In February 2015, Christina Applegate was awarded the Saint Vintage Love Cures Award at the 2nd annual unite4:humanity event hosted by Variety magazine for her dedication to and work with Right Action for Women.
In August 2021, Christina Applegate announced that she had been diagnosed with multiple sclerosis a few months prior. The disease significantly impacted her ability to perform in the final season of Dead to Me.
In 2023, Applegate stated that due to her illness, she would likely no longer act on camera. However, she expressed openness to voiceover work and working behind the scenes.