Sergio Brown (born May 22, 1988) is a former American football safety. He was signed by the New England Patriots as an undrafted free agent in 2010. He has also been a member of the Indianapolis Colts, Atlanta Falcons, Jacksonville Jaguars and Buffalo Bills.
At the University of Notre Dame, Brown primarily played special teams during his first two seasons, and became a starter in 2008 as a junior, starting 6 of 13 games and recording 28 tackles and one sack. As a senior, he started 12 games, and had 50 tackles and one sack.
After going undrafted in the 2010 NFL Draft, Brown signed with the New England Patriots on April 29, 2010. He was waived during final cuts on September 4, 2010, and re-signed to the team's practice squad the next day. After spending the first six weeks of the season on the practice squad, Brown was promoted to the 53-man roster on October 23. He made his NFL debut the next day against the San Diego Chargers, recording four tackles in the game. In total, Brown played in 11 games for the Patriots in 2010, all as a reserve. He finished the season with 11 tackles.
Sergio Brown was waived by the Patriots on August 31, 2012, during final cuts before the beginning of the 2012 NFL season.
Brown signed with the Indianapolis Colts on September 1, 2012.
Brown signed with the Jacksonville Jaguars on March 11, 2015.
On April 18, 2016, the Jaguars released Brown.
On August 20, 2016, Brown was signed by the Falcons. On August 27, 2016, Brown was waived by the Falcons.
On November 2, 2016, Brown was signed by the Buffalo Bills.
In September 2023, Maywood, Illinois police created a missing persons report for Brown after they found his mother dead near a creek behind her home in what was determined to be a homicide.