On 4 October 1998, Shadab Khan was born in Kamar Mushani, Mianwali District, Punjab, Pakistan.
In 2008, Shadab Khan's family shifted from Kamarmashani to Rawalpindi, where he joined Bajwa Cricket Club, a local cricket academy.
On 26 August 2016, Shadab Khan made his Twenty20 debut for Rawalpindi in the 2016–17 National T20 Cup.
In 2016, an ESPNcricinfo feature profile noted Shadab Khan as Pakistan’s emerging “mystery” legspinner, outlining his repertoire and approach to bowling.
In the 2nd unofficial Test at Bulawayo in 2016, Shadab Khan scored his maiden first-class century (129) for Pakistan A and took 5 wickets in Zimbabwe A’s second innings.
In April 2017, Shadab Khan made his One Day International (ODI) debut and his Test debut for Pakistan against the West Indies. He was part of Pakistan's 2017 Champions Trophy winning squad.
In an April 2017 interview, Shadab Khan discussed his bowling style, emphasizing that his leg-break and flipper are also wicket-taking options.
In September 2017, Shadab Khan was named the PCB's Emerging Player of the Year.
On 16 October 2017, against Sri Lanka, Shadab Khan scored his maiden ODI fifty. He was adjudged the man of the match for his all-round performances.
In 2017, after his performance in the ICC Champions Trophy, Shadab Khan signed to play for Trinbago Knight Riders in the Caribbean Premier League and later signed with the Brisbane Heat for the 7th season of the Big Bash League.
In April 2019, Shadab Khan was named to Pakistan's squad for the 2019 Cricket World Cup, but was later ruled out of Pakistan's preceding tour of England with a virus.
On 23 June 2019, in Pakistan's World Cup match against South Africa, Shadab Khan took his 50th wicket in ODIs.
In late September 2019, Shadab Khan said he aimed to become a genuine all-rounder for Pakistan, stressing ongoing work on his batting alongside his leg-spin so he can contribute in multiple roles and improve team balance.
In June 2020, Shadab Khan was named in a 29-man squad for Pakistan's tour to England during the COVID-19 pandemic. However, on 22 June 2020, Khan was one of three players from Pakistan's squad to test positive for COVID-19.
On 28 August 2020, in the first T20I match against England, Shadab Khan took his 50th wicket in the format.
On 18 December 2020, Shadab Khan captained the Pakistan team for the first time in an international match, leading the team in the first Twenty20 International (T20I) against New Zealand due to Babar's injury.
In 2020, an analysis of PSL noted Shadab Khan’s return to form with the bat, elevated to No. 4 for Islamabad United, showcasing his batting evolution.
In September 2021, Shadab Khan was named the vice-captain of Pakistan's squad for the 2021 ICC Men's T20 World Cup.
A post–2022 Asia Cup final analysis argues Khan had “got his groove back,” highlighting his all-round resurgence through the tournament
In 2022, Shadab Khan was amongst the players centrally contracted by the Pakistan Cricket Board (PCB).
On 27 March 2023, Shadab Khan took his 100th T20I wicket against Afghanistan, and became the first male cricketer from Pakistan to take 100 wickets in T20Is.
In May 2024, Shadab Khan was named in Pakistan's squad for the 2024 ICC Men's T20 World Cup tournament.
In August 2025, Shadab Khan completed his diploma in business management from Inspire London College (ILC).
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