Novo Nordisk A/S is a Danish multinational pharmaceutical company headquartered in Bagsværd. It has production facilities across nine countries, and affiliates or offices in five. Novo Holdings A/S controls Novo Nordisk, holding roughly 28% of its shares and a majority (77%) of the voting shares.
In 1922, August Krogh and his wife Marie visited Toronto during a lecture tour, where they learned about the recent manufacturing of active insulin by Frederick Banting, Charles Best, and John Macleod.
In 1923, August Krogh joined forces with Hans Christian Hagedorn to start insulin production in Denmark, leading to the establishment of Nordisk Insulinlaboratorium company.
In 1925, brothers Harald and Thorvald Pedersen, former employees of Nordisk, established their own company, Novo Terapeutisk Laboratorium.
In 1982, Novo Nordisk established its presence in the United States.
In 1986, Novo Industri A/S acquired the Ferrosan Group, which was later renamed "Novo Nordisk Pharmatech A/S."
In 1989, Novo Industri A/S (Novo Terapeutisk Laboratorium) and Nordisk Gentofte A/S (Nordisk Insulinlaboratorium) merged to become Novo Nordisk A/S, the world's largest producer of insulin.
In 1989, Novo Nordisk was created through the merger of two Danish companies that originated in the 1920s.
In 1989, Novo Terapeutisk Laboratorium and Nordisk Insulinlaboratorium merged to form Novo Nordisk A/S.
In 1991, Novo Nordisk Engineering (now NNE A/S) demerged to provide standard engineering services to pharma manufacturing companies.
In 1994, Novo Nordisk's existing information technology units were spun out as NNIT A/S.
In 2000, Novo's enzymes business, Novozymes A/S, was spun out.
In 2001, Novo Nordisk conducted the DAWN (Diabetes Attitudes, Wishes and Needs) 2001 study, a global survey of the psychosocial aspects of living with diabetes, involving over 5,000 people with diabetes and almost 4,000 care providers, designed to identify barriers to optimal health and quality of life.
In 2004, NNIT A/S was converted into a wholly owned aktieselskab.
In 2010, Novo Nordisk breached the code of conduct for the Association of the British Pharmaceutical Industry (ABPI) by not providing information about the side-effects of Victoza and promoting Victoza before market authorization.
In 2010, Novo Nordisk was ranked 25th among Fortune's 100 Best Companies to Work For.
In January 2012, Novo Nordisk was named the most sustainable company in the world by Corporate Knights magazine.
In 2012, Novo Nordisk completed a follow-up study to DAWN, involving more than 15,000 people living with, or caring for, those with diabetes.
In March 2013, scientists debated whether the incretin class of diabetic medications, including Victoza, had an increased risk of pancreas side effects such as pancreatitis and pancreatic cancer, but concluded available data did not confirm these concerns.
In October 2013, batches of NovoMix 30 FlexPen and Penfill insulin were recalled in some European countries because analysis showed a small percentage did not meet specifications for insulin strength.
In 2013, Novo Nordisk had to pay back 3.6 billion kr. to the Danish tax authorities due to transfer mispricing.
In 2013, Novo acquired Xellia for $700 million.
In March 2014, Novo Nordisk announced a partnership program entitled ‘Cities Changing Diabetes,’ which entails combating urban diabetes, in partnership with University College London (UCL) and supported by Steno Diabetes Center.
In September 2014, Novo Nordisk decided to discontinue all research in inflammatory disorders, including the R&D of anti-IL-20 for rheumatoid arthritis treatment.
In November 2014, a newspaper article suggested that a recent medical research breakthrough at Harvard University (creating insulin-producing cells from embryonic stem cells) could potentially put Novo Nordisk out of business. Novo Nordisk's chief medical officer, Dr Alan Moses, commented that Novo Nordisk's mission is to alleviate and cure diabetes and if this new medical advance meant the dissolution of Novo Nordisk, that'd be fine.
In 2014, Novo Nordisk was ranked 72nd in Fortune's 100 Best Companies to Work For.
In 2015, Novo Nordisk announced a collaboration with Ablynx to develop at least one new drug candidate using nanobody technology.
In September 2017, Novo Nordisk agreed to pay $58.7 million to end a United States Department of Justice probe into the lack of FDA disclosure to doctors about the cancer risk for their diabetic drug, Victoza.
In 2017, Novo Nordisk was ranked 73rd in Fortune's 100 Best Companies to Work For.
In January 2018, Reuters reported Novo Nordisk's offer to acquire Ablynx for $3.1 billion, which was rejected. Later in the same year, Novo Nordisk announced it would acquire Ziylo for around $800 million.
In September 2018, Novo Nordisk announced it would lay off 400 administrative staff, laboratory technicians, and scientists in Denmark and China to focus research and development efforts on "transformational biological and technological innovation".
In March 2020, Novo volunteers started testing samples for SARS-CoV-2 using RT-qPCR equipment to increase testing capacity during the coronavirus pandemic.
In November 2021, Novo Nordisk announced it would acquire Dicerna Pharmaceuticals and its RNAi therapeutics for $3.3 billion.
In September 2022, Novo Nordisk agreed to acquire Forma Therapeutics for $1.1 billion to expand its portfolio in sickle cell disease and rare blood disorders.
In 2022, the popularity of Novo's Wegovy and Ozempic significantly increased the growth of the entire economy of Denmark, with two-thirds of the country's overall economic growth attributed to the pharmaceutical industry.
In March 2023, Novo Nordisk was suspended from the ABPI for two years for misleading marketing practices, and the Royal College of General Practitioners and the Royal College of Physicians ended their corporate partnerships. The Novo Nordisk UK General Manager, Pinder Sahota, resigned as President of the ABPI before the suspension.
In August 2023, Novo Nordisk agreed to acquire Inversago Pharma for $1 billion and Embark Biotech for up to $500 million.
In September 2023, Novo Nordisk and UNICEF announced a multi-year expansion of their collaboration to address childhood overweight and obesity.
In October 2023, Novo Nordisk announced it would acquire ocedurenone from KBP Biosciences for $1.3 billion. After a failed clinical trial, Novo Nordisk initiated legal action against KBP, seeking up to $830 million in damages and freezing KBP's assets.
In November 2023, Novo Nordisk announced an investment of €2.1 billion in a French production facility to increase the production capacity and manufacturing of its popular anti-obesity medication.
In 2023 alone, Novo Nordisk hired over 10,000 people to support its shift towards a more ambitious mission to "defeat serious chronic diseases".
In 2023, Novo Nordisk's market capitalization exceeded the GDP of Denmark's domestic economy, making it the highest valued company in Europe, with revenue reaching US$33.724 billion.
In 2023, Novo Nordisk's profits increased by 45% year over year in the first half of the year, largely due to its weight loss drugs, Wegovy and Ozempic, which accounted for 55% of the company's revenue.
On February 2, 2024, The United States Judicial Panel on Multidistrict Litigation ordered that 55 lawsuits pending in federal courts be consolidated into a multidistrict litigation. The Ozempic Lawsuits allege gastroparesis ileus and other injuries caused by GLP-1 RAS. The Case is known as MDL No. 3094 In Re: Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAS) Products Liability Litigation.
In February 2024, Novo Holdings A/S agreed to acquire Catalent for $16.5 billion. Upon completion, Novo Nordisk planned to acquire three manufacturing facilities from its parent for $11 billion to scale up production of Wegovy and Ozempic.
In March 2024, Novo Nordisk reached a $604 billion market capitalization, becoming the 12th most valuable company in the world. The company also announced it would acquire Cardior Pharmaceuticals and its cardiovascular disease portfolio for up to $1.1 billion.
As of April 2024, Novo Nordisk's weight-loss drugs solidified its status as the most valuable company in Europe. Its $570 billion market capitalization exceeded Denmark's entire economy, and its growth was driving nearly all of the country's economic expansion. The company's $2.3 billion income tax bill for 2023 made it the largest taxpayer in the country.
In May 2024, Novo Nordisk announced it would acquire Austrian fluid management service business, Single Use Support.
In June 2024, Novo Nordisk announced plans to build a new production plant in Clayton, North Carolina, at a cost of $4.1 billion for production of semaglutide products Ozempic and Wegovy. The company also announced plans to acquire US-based Catalent to increase production supply.
In July 2024, US President Joe Biden joined Sanders in stating "Novo Nordisk and Eli Lilly must stop ripping off Americans with high drug prices." Novo Nordisk drug pricing in the US has been a target of lawmakers. The committee investigation found Novo Nordisk's drug Ozempic priced for $969 per month in the US, compared to $155 in Canada and $59 in Germany. Its weight-loss drug Wegovy is priced for $1,349 per month in the US compared to $140 in Germany and $92 in the UK.
As of August 6, 2024 there were 235 active Ozempic lawsuits.
In September 2024, Novo Nordisk CEO Lars Fruergaard Jørgensen was summoned to testify to the US Senate Health, Education, Labor and Pensions Committee in Washington DC. During the hearing Senator Bernie Sanders told the Novo Nordisk CEO, "Stop Ripping Us Off."
As of October 2024, Novo Nordisk was the second most valuable drug company in the world by market capitalization, only behind its competitor Eli Lilly and Company.
In October 2024, Novo Nordisk published a study in the scientific journal Nature about a novel glucose-sensitive insulin NNC2215 that can reduce the risk of hypoglycemia in animal models.
For the fiscal year 2024, Novo Nordisk reported earnings of DKK 101 billion (around 14.5 billion USD), with an annual revenue of DKK 290.4 billion (around 42.1 billion USD), an increase of 25% over the previous fiscal cycle.
In March 2025, Novo Nordisk announced new plans for a direct-to-consumer offering of its Wegovy weight loss drug through a new pharmacy, NovoCare, charging customers $499 per month.
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